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🏆 Favorite: The Cardinals are underdogs against the 49ers in Week 5.
💪 Cardinals' Chances: Arizona has a 25.23% chance to beat the Niners.
👀 Point Spread: The Cardinals are +7.5 vs. the 49ers.
📝 Over/Under: The over/under for Cardinals vs. 49ers is set at 50 points.
💲 Moneyline: The Cardinals' moneyline is +280, while the 49ers' is -355.
The Arizona Cardinals will play NFC West rival San Francisco 49ers two times in 2024. The first matchup in Week 5 will be in San Francisco on a Sunday at 1:05 p.m. PT, while the Cardinals will be at home for the Week 18 game which will either be on a Saturday or Sunday.
Here you'll find the best odds and lines for Cardinals vs. 49ers found at Arizona sportsbooks.
The San Francisco 49ers are favored to beat the Cardinals in both their Week 5 and Week 18 matchups. That could always change as the season progresses, so you'll want to keep an eye on the line if you're thinking about betting on it.
What's the Point Spread?
The point spread for Cardinals vs. 49ers in Week 5 is 49ers -7.5, Cardinals +7.5. This makes the 49ers heavy favorites, which is expected considering they are the defending NFC champions.
What's the Moneyline?
The moneyline for Cardinals vs. 49ers is set at AZ +280 and SF -355. Betting $100 on +280 would earn $280 plus your $100 back if the Cards win. Meanwhile, betting $100 on the Niners would earn you just $28.17 plus your $100 back if the 49ers win straight up.
What's the Over/Under?
The game total for the Cardinals and 49ers Week 5 game is set at over/under 50 points. This suggests an average to high scoring game between the two, with each teams scoring in the 20s.
Arizona Cardinals Chances to Win vs. San Francisco 49ers
The Cardinals have a 25.23% chance to beat the 49ers in Week 5. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using +280 odds for the Cardinals and -355 odds for the 49ers:
However, the above percentages add up to 104.34%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 104.34.
Note that both of the final team chances above finally equal 100%. Hence, the 25.23% chance to win for the Cardinals.
How Arizona Wins vs. San Francisco
This one will mainly hinge on Cardinals quarterback Kyler Murray's ability. He has played well so far this season, establishing a solid rapport with rookie receiver Marvin Harrison Jr. who is the team's leading receiver. However, the Niners pose a tough challenge that will be difficult for Arizona to overcome.
The 49ers made the Super Bowl last year and barely lost to the Kansas City Chiefs in overtime. They'll be looking to get back to the big game, which means they should have one of the NFL's best squads again in 2024. To win this one, the Niners will simply need to play mistake-free football and make sure Arizona doesn't capitalize on any errors they may make.
How to Watch Cardinals vs. 49ers
The Cardinals vs. 49ers Week 5 game will air on FOX in local markets at 1:05 p.m. PT. Out-of-market fans can catch the game on NFL Sunday Ticket, which is exclusively on YouTube TV. Check 506sports.com to see if you get the game in your local market.
Exclusive Promos for Betting on the Game
There are many Arizona sports betting promos available to use for the Cardinals vs. 49ers game. These promos can also be used on props, futures and other bets:
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Must be 21+ to participate & present in Arizona. Gambling Problem? Call 1-800-NEXT-STEP. Deposit required. Bonus Bets winnings are added to Bonus Bets balance. Bonus Bet wager excluded from returns. T&Cs Apply.
The widget below uses predictive analytics and projections to find potential betting edges. Be sure to do your own research before making any wagers.
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History of Cardinals vs. 49ers
The Cardinals and 49ers have played each other 65 times dating way back to 1951 when the Cardinals were called the Chicago Cardinals (and later St. Louis Cardinals, then later Phoenix Cardinals before becoming the Arizona Cardinals).
Record All-Time
The 49ers lead the all-time series 36-29 over the Cardinals, and have won each of the last four matchups between the two.
Most Recent Matchup
The last game between the Cardinals and Niners was played on December 17, 2023. The 49ers won that game 45-29 with QB Brock Purdy throwing for four touchdowns.
Top 5 Games
Date
Matchup
Winner
Oct. 31, 2019
SF @ AZ
49ers 28-25
Nov. 25, 2007
SF @ AZ
49ers 37-31
Dec. 12, 2004
SF @ AZ
49ers 31-28
Oct. 10, 2004
AZ @ SF
49ers 31-28
Nov. 6, 1988
SF @ PHX
Cardinals 24-23
FAQs
The 49ers are 7.5-point favorites over the Cardinals in Week 5.
The over/under for Cardinals vs. 49ers is 50 total points.
You can place bets on the Cardinals vs. 49ers at any legal sportsbook in Arizona. You just have to be 21 or older, within state lines and signed up for an account on your chosen betting app. Be sure to use a promo to maximize your earnings.
The Cardinals and 49ers play in Week 5 of the 2024 NFL season on Sunday, October 6 at 1:05 p.m. PT. They'll play again in Week 18 on either Saturday, January 4 or Sunday, January 5. Time is TBD for Week 18.
The Cardinals vs. 49ers game in Week 5 will be aired live on FOX in local markets. Out-of-market viewers can get NFL Sunday Ticket on YouTube TV. Their Week 18 game is TBD. Check 506sports.com to see if you'll get the games in your local market.
Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.
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