👇 Cardinals vs. 49ers Odds: Quick Facts 👇
Here are the most important facts related to odds for AZ vs. SF:
| ⭐ Favorite | San Francisco 49ers |
| 🔢 Point Spread | Cardinals -4.5, 49ers +4.5 |
| 📊 Moneyline | Cardinals -218, 49ers +180 |
| 📈 Game Total | Over/under 42.5 points |
| ✅ Last Verified | January 17, 2025 |
Odds via DraftKings Sportsbook.
Who Is Favored to Win?
The Cardinals are favored to beat the Niners in Week 18.
What's the Point Spread?
The point spread for Cardinals vs. 49ers in Week 18 is 49ers +4.5, Cardinals -4.5. The line changed a bit after it was announced that QB Brock Purdy would not start for the Niners.
What's the Moneyline?
The moneyline for Cardinals vs. 49ers is set at AZ -198 and SF +164. Betting $100 on -198 would earn $50.51 plus your $100 back if the Cards win. Meanwhile, betting $100 on the Niners would earn you $164 plus your $100 back if the 49ers win straight up.
What's the Over/Under?
The game total for the Cardinals and 49ers Week 18 game is set at over/under 42.5 points. This suggests an average to low scoring game between the two.
Related Cardinals Betting Content:
Arizona Cardinals Chances to Win vs. San Francisco 49ers
The Cardinals have a 65.75% chance to beat the 49ers in Week 18. Their chances are calculated using implied probability based on odds from DraftKings. Here is how it is calculated for each team using -218 odds for the Cardinals and +180 odds for the 49ers:
Cardinals chances: 218 ÷ (218 + 100) * 100 = 68.55%
49ers chances: 100 ÷ (180 + 100) * 100 = 35.71%
However, the above percentages add up to 104.26%. This is due to the vig, which is the house edge for the sportsbook which allows them to profit off the bet. To remove the vig, we simply divide each team's chance by 104.26.
Cardinals chances (after vig): 68.55 ÷ 104.26 = 65.75%
49ers chances (after vig): 35.71 ÷ 104.26 = 34.25%
Note that both of the final team chances above finally equal 100%. Hence, the 65.75% chance to win for the Cardinals.
How Arizona Wins vs. San Francisco
Since both teams are eliminated from playoff contention, this game is mostly about pride. This one will mainly hinge on Cardinals quarterback Kyler Murray's ability. He played well this season, though the team still has some things to clean up in order to compete in 2025. In the meantime, Murray will need to rely on his top stars to get a win over a tough 49ers squad.
Other Cardinals Matchups This Season:
How San Francisco Wins vs. Arizona
The Niners have a lot of players sitting out for this game due to injuries and rest. Simply put, there's no reason for the Niners to play some of those top guys since they're already eliminated from postseason contention. If the Niners want to win this one, they'll have to rely on some of their young talent that has stepped up in the absence of some of San Francisco's injured stars.
How to Watch Cardinals vs. 49ers
The Cardinals vs. 49ers Week 18 game will air on FOX in local markets at 1:25 p.m. PT. Out-of-market fans can catch the game on NFL Sunday Ticket, which is exclusively on YouTube TV. Check 506sports.com to see if you get the game in your local market.
Exclusive Promos for Betting on the Game
There are many Arizona sports betting promos available to use for the Cardinals vs. 49ers game. These promos can also be used on props, futures and other bets:
Best Prop Picks for Cardinals vs. 49ers
The widget below uses predictive analytics and projections to find potential betting edges. Be sure to do your own research before making any wagers.
History of Cardinals vs. 49ers
The Cardinals and 49ers have played each other 66 times dating way back to 1951 when the Cardinals were called the Chicago Cardinals (and later St. Louis Cardinals, then later Phoenix Cardinals before becoming the Arizona Cardinals).
Record All-Time
The 49ers lead the all-time series 36-30 over the Cardinals, and were on a four-game winning streak before losing to the Cards early in the 2024 season.
Most Recent Matchup
The last game between the Cardinals and Niners was played on October 6, 2024. The Cards won that game 24-23 with QB Kyler Murray and RB James Conner rushing for a combined 169 yards and a touchdown.
Top 5 Games
| Date | Matchup | Winner |
|---|---|---|
| Oct. 31, 2019 | SF @ AZ | 49ers 28-25 |
| Nov. 25, 2007 | SF @ AZ | 49ers 37-31 |
| Dec. 12, 2004 | SF @ AZ | 49ers 31-28 |
| Oct. 10, 2004 | AZ @ SF | 49ers 31-28 |
| Nov. 6, 1988 | SF @ PHX | Cardinals 24-23 |
FAQs
The Cards are 4.5-point favorites over the Niners in Week 18.
The over/under for Cardinals vs. 49ers is 42.5 total points.
You can place bets on the Cardinals vs. 49ers at any legal sportsbook in Arizona. You just have to be 21 or older, within state lines and signed up for an account on your chosen betting app. Be sure to use a promo to maximize your earnings.
The Cardinals and 49ers play in Week 18 on Sunday, January 5. Kickoff is set for 1:25 p.m. PT.
The Cardinals vs. 49ers game in Week 18 will be aired live on FOX in local markets. Out-of-market viewers can get NFL Sunday Ticket on YouTube TV. Check 506sports.com to see if you'll get the games in your local market.
Author
Wes is an editor and writer for BetArizona.com. Based out of the Kansas City area, Wes has covered sports professionally since 2015 with a strong emphasis on sports betting and the NFL, though he's also covered pro wrestling, UFC, college sports and more.
